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Rossi John J. RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
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An easily accessible introduction to log-linear modeling for non-statisticians Highlighting advances that have lent to the topic's distinct, coherent methodology over the past decade, Log-Linear Modeling: Concepts, Interpretation, and Application provides an essential, introductory treatment of the subject, featuring many new and advanced log-linear methods, models, and applications. The book begins with basic coverage of categorical data, and goes on to describe the basics of hierarchical log-linear models as well as decomposing effects in cross-classifications and goodness-of-fit tests. Additional topics include: The generalized linear model (GLM) along with popular methods of coding such as effect coding and dummy coding Parameter interpretation and how to ensure that the parameters reflect the hypotheses being studied Symmetry, rater agreement, homogeneity of association, logistic regression, and reduced designs models Throughout the book, real-world data illustrate the application of models and understanding of the related results. In addition, each chapter utilizes R, SYSTAT®, and §¤EM software, providing readers with an understanding of these programs in the context of hierarchical log-linear modeling. Log-Linear Modeling is an excellent book for courses on categorical data analysis at the upper-undergraduate and graduate levels. It also serves as an excellent reference for applied researchers in virtually any area of study, from medicine and statistics to the social sciences, who analyze empirical data in their everyday work.
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A practical guide to analysing partially observed data. Collecting, analysing and drawing inferences from data is central to research in the medical and social sciences. Unfortunately, it is rarely possible to collect all the intended data. The literature on inference from the resulting incomplete data is now huge, and continues to grow both as methods are developed for large and complex data structures, and as increasing computer power and suitable software enable researchers to apply these methods. This book focuses on a particular statistical method for analysing and drawing inferences from incomplete data, called Multiple Imputation (MI). MI is attractive because it is both practical and widely applicable. The authors aim is to clarify the issues raised by missing data, describing the rationale for MI, the relationship between the various imputation models and associated algorithms and its application to increasingly complex data structures. Multiple Imputation and its Application: Discusses the issues raised by the analysis of partially observed data, and the assumptions on which analyses rest. Presents a practical guide to the issues to consider when analysing incomplete data from both observational studies and randomized trials. Provides a detailed discussion of the practical use of MI with real-world examples drawn from medical and social statistics. Explores handling non-linear relationships and interactions with multiple imputation, survival analysis, multilevel multiple imputation, sensitivity analysis via multiple imputation, using non-response weights with multiple imputation and doubly robust multiple imputation. Multiple Imputation and its Application is aimed at quantitative researchers and students in the medical and social sciences with the aim of clarifying the issues raised by the analysis of incomplete data data, outlining the rationale for MI and describing how to consider and address the issues that arise in its application.
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Written in a clear and understandable manner, this book provides a comprehensive, yet non-mathematical, treatment of the topic, covering the basic principles of symmetry and the important spectroscopic techniques used to probe molecular structure. The chapters are extensively illustrated and deal with such topics as symmetry elements, operations and descriptors, symmetry guidelines, high-fidelity pseudosymmetry, crystallographic symmetry, molecular gears, and experimental techniques, including X-ray crystallography and NMR spectroscopy. As an additional feature, 3D animations of most of the structures and molecules covered are available online at wiley.com. As a result, chemists learn how to understand and predict molecular structures and reactivity. Authored by a renowned expert with numerous publications and an excellent track record in research and teaching, this is a useful source for graduate students and researchers working in the field of organic synthesis, physical chemistry, biochemistry, and crystallography, while equally serving as supplementary reading for courses on stereochemistry, organic synthesis, or crystallography.
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William Congreve A treatise on the general principles, powers, and facility of application of the Congreve Rocket System, as compared with artillery
Полный вариант заголовка: «A treatise on the general principles, powers, and facility of application of the Congreve Rocket System, as compared with artillery : showing the various applications of this weapon, both for sea and land service, and its different uses in the field and in sieges : illustrated by plates of the principal exercises and cases of actual service : with a demonstration of the comparative economy of the system / by Sir W. Congreve».
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This volume seeks to facilitate such exposure by drawing together into a convenient collection the fine articles on CBA and its application that have appeared in the Journal of Policy Analysis and Management (JPAM).
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Defending your web applications against hackers and attackers The top-selling book Web Application Hacker's Handbook showed how attackers and hackers identify and attack vulnerable live web applications. This new Web Application Defender's Cookbook is the perfect counterpoint to that book: it shows you how to defend. Authored by a highly credentialed defensive security expert, this new book details defensive security methods and can be used as courseware for training network security personnel, web server administrators, and security consultants. Each «recipe» shows you a way to detect and defend against malicious behavior and provides working code examples for the ModSecurity web application firewall module. Topics include identifying vulnerabilities, setting hacker traps, defending different access points, enforcing application flows, and much more. Provides practical tactics for detecting web attacks and malicious behavior and defending against them Written by a preeminent authority on web application firewall technology and web application defense tactics Offers a series of «recipes» that include working code examples for the open-source ModSecurity web application firewall module Find the tools, techniques, and expert information you need to detect and respond to web application attacks with Web Application Defender's Cookbook: Battling Hackers and Protecting Users.
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Metal-organic frameworks represent a new class of materials that may solve the hydrogen storage problem associated with hydrogen-fueled vehicles. In this first definitive guide to metal-organic framework chemistry, author L. MacGillivray addresses state-of-art developments in this promising technology for alternative fuels. Providing professors, graduate and undergraduate students, structural chemists, physical chemists, and chemical engineers with a historical perspective, as well as the most up-to-date developments by leading experts, Metal-Organic Frameworks examines structure, symmetry, supramolecular chemistry, surface engineering, metal-organometallic frameworks, properties, and reactions.
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Forensic Case Formulation is the first text that describes the principles and application of case formulation specifically to forensic clinical practice. Addresses risk assessment and its implications for case formulation and treatment Covers a range of serious forensic problems such as violence, sexual offending, personality disorder, and substance misuse Offers guidance in training clinicians on ways to create useful formulations
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This book reviews chiral polymer synthesis and its application to asymmetric catalysis. It features the design and use of polymer-immobilized catalysts and methods for their design and synthesis. Chapters cover peptide-catalyzed and enantioselective synthesis, optically-active polymers, and continuous flow processes. It collects recent advances in an important field of polymer and organic chemistry, with leading researchers explaining applications in academic and industry R & D.
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Antonio Napolitano Generalizations of Cyclostationary Signal Processing. Spectral Analysis and Applications
The relative motion between the transmitter and the receiver modifies the nonstationarity properties of the transmitted signal. In particular, the almost-cyclostationarity property exhibited by almost all modulated signals adopted in communications, radar, sonar, and telemetry can be transformed into more general kinds of nonstationarity. A proper statistical characterization of the received signal allows for the design of signal processing algorithms for detection, estimation, and classification that significantly outperform algorithms based on classical descriptions of signals.Generalizations of Cyclostationary Signal Processing addresses these issues and includes the following key features: Presents the underlying theoretical framework, accompanied by details of their practical application, for the mathematical models of generalized almost-cyclostationary processes and spectrally correlated processes; two classes of signals finding growing importance in areas such as mobile communications, radar and sonar. Explains second- and higher-order characterization of nonstationary stochastic processes in time and frequency domains. Discusses continuous- and discrete-time estimators of statistical functions of generalized almost-cyclostationary processes and spectrally correlated processes. Provides analysis of mean-square consistency and asymptotic Normality of statistical function estimators. Offers extensive analysis of Doppler channels owing to the relative motion between transmitter and receiver and/or surrounding scatterers. Performs signal analysis using both the classical stochastic-process approach and the functional approach, where statistical functions are built starting from a single function of time.
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Nanotechnology, especially microfabrication, has been affecting every facet of traditional scientific disciplines. The first book on the application of microfluidic reactors in nanotechnology, Microfluidic Devices in Nanotechnology provides the fundamental aspects and potential applications of microfluidic devices, the physics of microfluids, specific methods of chemical synthesis of nanomaterials, and more. As the first book to discuss the unique properties and capabilities of these nanomaterials in the miniaturization of devices, this text serves as a one-stop resource for nanoscientists interested in microdevices.
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An authoritative yet highly accessible guide to the design and operation of the FlexRay bus, the latest protocol for automotive network communications A translation of the French edition, originally published in January 2011, this work is the result of numerous training courses that Dominique Paret has given in companies, and it provides detailed explanations of the design and operation of the FlexRay bus. Comprised of five parts the book covers: the FlexRay concept and its communication protocol; the FlexRay physical layer; synchronization and global time and; architecture of a node, components and development aid tools for hardware and software. Provides comprehensive treatment of the FlexRay network, including its implementation through a real automotive application Includes the latest specifications (Version 3) concluded by the FlexRay consortium widely expected to become the industry standard Written by an author with in-depth experience of automotive electronics, including FlexRay, and presenter of specialist training courses to the industry Includes a review of industrial tools to help design and implement a FlexRay based distributor application
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The monograph is devoted to a problem of production and sale of the concentrating and mountain equipment. The economic evaluation of production and sale is opened in the following sequence. The economic essence of the concept «insolvency» of the entity is stated. The reasons of risk of insolvency, its role in diagnostic approaches to solvency analysis of the entity, are called and analysed possibilities of a risk assessment of insolvency of the entity. By means of assessment of a condition the model of the analysis and a risk assessment of insolvency of the entity, an algorithm of its application in the analysis of machine-building enterprise is developed. Assessment of a condition of production and sale is carried out based on huge statistical material on influence of structure and structure of current assets on solvency of machinebuilding enterprise, liquidity of balance and assessment of liquidity and efficiency of cash flows for strengthening and optimization of activities. With use of integration of methods approbation of an analysis technique and a risk assessment of insolvency of machine-building enterprise is carried out and the possibilities of its optimization are considered. In an analysis result, assessment and developed offers the management concept is formulated by liquidity of machine-building enterprise and decrease in risk of insolvency, the principles of its forming and the mechanism of implementation are shown.
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This book is the first to bring together new research to offer a hands-on clinical guide to treating people with all types of obsessive compulsive disorder (OCD) using an inference-based therapy (IBT). Provides clinical examples from the full range of OCD subtypes Coverage integrates theory and application Decribes case management in detail – from initial assessment to terminating therapy and follow-up Shows how IBT can also be generalized and applied to other serious psychiatric disorders
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Details the water research applications of nanotechnology in various areas including environmental science, remediation, membranes, nanomaterials, and water treatment At the nano size, materials often take on unique and sometimes unexpected properties that result in them being ‘tuned’ to build faster, lighter, stronger, and more efficient devices and systems, as well as creating new classes of materials. In water research, nanotechnology is applied to develop more cost-effective and high-performance water treatment systems, as well as to provide instant and continuous ways to monitor water quality. This volume presents an array of cutting-edge nanotechnology research in water applications including treatment, remediation, sensing, and pollution prevention. Nanotechnology applications for waste water research have significant impact in maintaining the long-term quality, availability, and viability of water. Regardless of the origin, such as municipal or industrial waste water, its remediation utilizing nanotechnology can not only be recycled and desalinized, but it can simultaneously detect biological and chemical contamination. Application of Nanotechnology in Water Research describes a broad area of nanotechnology and water research where membrane processes (nanofiltration, ultrafiltration, reverse osmosis, and nanoreactive membranes) are considered key components of advanced water purification and desalination technologies that remove, reduce, or neutralize water contaminants that threaten human health and/or ecosystem productivity and integrity. Various nanoparticles and nanomaterials that could be used in water remediation (zeolites, carbon nanotubes, self-assembled monolayer on mesoporous supports, biopolymers, single-enzyme nanoparticles, zero-valent iron nanoparticles, bimetallic iron nanoparticles, and nanoscale semiconductor photocatalysts) are discussed. The book also covers water-borne infectious diseases as well as water-borne pathogens, microbes, and toxicity approach.
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